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He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. 2012 Jul; 36(1):22-9. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2014 Aug; 124(8):3566-78. 2008 Nov; 135(5):1729-38. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 2016 Mar; 13(3):126-8. 2002 Dec; 36(6):1498-508. A molecular defect in human protoporphyria. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. 2009 Sep; 1(8-9):513-24. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. 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Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. 2003 Sep; 285(3):G642-51. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Int J Stroke. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. 2007 Aug; 47(2):307-9. Hepatology. JCI Insight. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 2004 Nov; 40(5):1106-15. 2015 Dec; 149(7):1784-93. Methods for analyzing c-Jun kinase. Gastroenterology. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. 2003 May; 73(1):44-52. 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Radiation exposure from depleted uranium: The radiation bystander effect. 1996 Feb; 23(2):379-80. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. 2001 Dec; 35(6):749-55. 1990 Feb; 10(1):75-83. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 2017 12 21; 2(24). Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. Analysis of the human ferrochelatase promoter in transgenic mice. 1997 Sep; 17(9):5201-9. 2021 05; 134:105933. Integr Biol (Camb). Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 1994 Sep; 17(3):410-2. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. 2005 Jul 29; 280(30):27879-87. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Gastroenterology. Curr Opin Gastroenterol. 2012 Jun 12; 109(24):9448-53. 2021; 12(1):293-320. Kenji Fujiwara, MD, PhD. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 1996 Nov; 271(5 Pt 1):G780-90. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 2003 May; 37(5):1043-55. Hepatol Commun. 2018 01; 61:132-137. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. J Clin Gastroenterol. 2006 Apr; 43(4):872-8. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Liver Int. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Antioxid Redox Signal. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Pharm Res. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. WebBrenners new job suits his eclecticism. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. What goes up must come down: the emerging role of microRNA in fibrosis. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. 2016 08; 65(2):369-76. 2012 Nov; 143(5):1330-1340.e1. Am J Physiol Gastrointest Liver Physiol. Mitogens and hepatocyte growth control in vivo and in vitro. 1989 May; 8(4):279-85. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 2021 03; 18(3):151-166. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. J Hepatol. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 1998 Jun; 42(6):779-87. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. 2000 Dec; 32(6):1272-9. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. J Clin Invest. Am J Physiol. J Gastroenterol Hepatol. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. J Biol Chem. The CAAX 2017 12; 1(10):1043-1057. 2014 Jul 21; 5:4451. 2006 Sep; 291(3):G456-63. Proc Am Thorac Soc. Nat Immunol. In Vitro Cell Dev Biol. 1990 Jan; 85(1):248-55. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. 2008 Jun; 118(6):2121-31. Thomas E. Starzl: Transplantation pioneer. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Exp Biol Med (Maywood). The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 2020; 4(5):561-580. Clin Gastroenterol Hepatol. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Gut. 1999 Jul; 5(4):282-93. J Hepatol. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. 2020 May 05; 56(5). The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 1988 Sep-Oct; 8(5):1040-5. Hepatology. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 2011 Mar 11; 286(10):8609-8619. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. 2000; 35 Suppl 12:80-3. 2000 Feb; 88(2):142-9. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2011 Jan 04; 108(1):308-13. 2010 Oct; 52(4):1390-400. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Hepatology. J Bone Miner Res. J Clin Invest. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Arch Biochem Biophys. Biochem Soc Symp. J Biol Chem. 2003 Oct; 125(4):1009. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. A method for in vitro DNase I footprinting analysis on supercoiled templates. J Natl Cancer Inst. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. The fecal microbiome of ALS patients. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 1988 Apr 15; 48(8):2288-91. The future of gastroenterology and gastroenterology. PLoS One. J Biol Chem. Dig Liver Dis. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Biotechniques. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. 1994 Dec; 124(6):755-60. J Hepatol. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 1995 Jul; 22(1):241-51. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. 2013 Feb 01; 12(3):381-2. J Clin Invest. Circ Res. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 2000 Feb; 31(2):391-8. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Antioxid Redox Signal. 2021 08 01; 321(2):H435-H445. 1999 09; 277(3):G671-7. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Leadership - Institute for Diabetes and Metabolic Health - UC San J Immunol. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. 1989 Aug 11; 17(15):6055-64. 2012 Aug; 143(2):307-20. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. 2006 Jul; 37(7):1691-6. Hepatobiliary Surg Nutr. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2000 Mar-Apr; 21(2):135-41. Transforming growth factor B and hepatic fibrosis: cause or effect? Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2003 Mar 07; 278(10):8083-90. Cell Death Differ. 2001 Jun 01; 166(11):6812-9. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 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