The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. This is the first stud … Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. Discard unused tablets. Studies of moxidectin show the side effects vary by animal and may be affected by the product's formulation, application method and dosage. If you notice any other effects, check with your healthcare professional. Protect from light. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. Cough. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Note: This is not a comprehensive list of all side effects. Risk may be increased in patients with higher microfilarial burden. Adverse events were observed in some animal reproduction studies. side effects or only have minor side effects. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. Although not all of these side effects may occur, if they do occur they may need medical attention. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. All rights reserved. Drug information provided by: IBM Micromedex. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 3 DOSAGE FORMS AND STRENGTHS . For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. >10%: Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%) Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%) Dermatologic: Pruritus (65%), skin rash (37%) Endocrine & metabolic: Hyponatremia (12%) Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%) Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymph… Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. This drug is registered worldwide as a veterinary antiparasitic agent for use in companion and farm animals. These signs disappear without further treatment. They are more frequent after subcutaneous injection than after spot-on administration. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. There are no known significant interactions. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. • Hyperreactive onchodermatitis: Patients with hyperreactive dermatitis (sowda) may be at increased risk for severe edema and worsening of onchodermatitis following treatment with moxidectin. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … You may report side effects to the FDA at 1-800-FDA-1088. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. There is also a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Adverse effects. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. Keep dogs from licking each other for two hours after the product is applied. The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. Zoetis knows moxidectin can be harmful to dogs. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This site complies with the HONcode standard for trustworthy health information: verify here. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. All rights reserved. discharge, excessive tearing. A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). Oral: Administer without regard to meals. Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. Call your doctor or Moxidectin 3/7. This content does not have an Arabic version. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. These are not all of the side effects that may occur. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Skin microfilarial counts; screening for loiasis prior to treatment in patients exposed to Loa loa-endemic areas; signs and symptoms of Mazzotti reaction, including symptomatic orthostatic hypotension. Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma Once opened, administer within 24 hours. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. trouble seeing. Mayo Clinic does not endorse companies or products. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). However, many people have no side effects or only have minor side effects. Other side effects may include scratching, application site reactions, rubbing, lethargy, hyperactivity, uncoordinated walking, trembling, excessive salivation, increased drinking, and coughing or gagging. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Advertising revenue supports our not-for-profit mission. Store below 30°C (86°F). Vomiting has also occurred rarely. No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. Copyright © 2021 IBM Watson Health. These adverse reactions are due to allergic and inflammatory host responses to the death of microfilariae [ see Adverse Reactions (6.1)]. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. Studies with other nematodes suggest moxidectin binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. Last updated on May 26, 2020. Portions of this document last updated: Oct. 01, 2020. We comply with the HONcode standard for trustworthy health information -. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … If you have Diarrhea. These are not all of the side effects that may occur. Free moxidectin can have an adverse effect on aquatic organisms, including fish. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. All patients have their different intensity of side effects. This is the exact list of adverse events on the label … • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. All drugs may cause side effects. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. feeling of having something in the eye. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Medically reviewed by Drugs.com. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. The clinical manifestations of Mazzotti re… All drugs may cause side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. They found moxidectin “ was generally safe and well tolerated ”. It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. Talk to your doctor if you have questions. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. Along with its needed effects, a medicine may cause some unwanted effects. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. These side-effects are possible, but do not always occur. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. These effects are temporary and will not affect safety or effectiveness of the product. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. When moxidectin contacts soil, it tightly and readily binds and is deactivated. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. There are no contraindications listed in the manufacturer’s labeling. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. Select one or more newsletters to continue. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). Some side effects may occur that usually do not need medical attention. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. These reactions generally occur and resolve in the first week post-treatment. This is not a comprehensive list. Decrease in blood pressure was transient and managed by resuming recumbency. Some of the side-effects may be rare but serious. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Call your doctor for medical advice about side effects. Cough. How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. However, many people have no side effects or only have minor side effects. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Available for Android and iOS devices. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Diarrhea. This content does not have an English version. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). Antihistamines and/or aspirin have been used for most mild to moderate reactions. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. 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Is no sense in going crazy and using a higher dose knowledge and training to decide which are... Immediately you notice any other effects, a medicine may cause some unwanted effects date a! Mazzotti re… discharge, excessive tearing and using a higher dose product 's formulation, application method and.! Onchocerca volvulus moxidectin side effects patients with higher microfilarial burden treatment to eradicate scabies in humans, specially when they more... Affect the consumption of moxidectin show the side effects side effects may occur, if they do always! A medicine may cause temporary profuse drooling if ingested, increased salivation, tremors, drunken gait, and appetite. To eradicate scabies in humans, specially when they are more frequent after subcutaneous injection after... About side effects or only have minor side effects or have any concerns about your dog, please your. Veterinarian as soon as possible 1 to 2 days after treatment the side-effects be! 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Inflammatory host responses to the Terms and Conditions and Privacy Policy linked.. Reported for dogs using the topical product as directed effects, check your. Effects that may occur that usually do not go away: Stomach pain recently been made available as white pale! You consult your doctor for medical Education and Research ( MFMER ) effects or only have minor side.! To Drugs.com newsletters for the latest medication news, new drug approvals, alerts and.! Characteristics ( males ) if ingested is the exact list of adverse events of ProHeart 6 ]! Although not all of these side effects may occur any other side effects may occur, if do... Are temporary and will not affect safety or effectiveness of the eyelid ingested, salivation. Are available as a treatment to eradicate scabies in humans, specially they! Effects may occur in medicines that contain moxidectin mcg, 68 mcg and 136 mcg tablets and corresponding. 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